The Nationwide Health Information Network (NHIN) implemented secure exchange of health records through utilization of the Internet. NHIN has greatly assisted in achieving the goals of the HITECH Act by promoting the adoption of Meaningful Use. Epic introduced a Health Information Exchange (HIE) platform, Care Everywhere (CE), which has facilitated HIE availability. The purpose of this research was to determine the impact of NHIN and Epic Care’s CE on healthcare to determine whether their use in the ED has increased. The methodology for this study utilized a literature review. Twenty-nine sources were referenced for this study. With the NHIN implementation, repeated visits were decreased, visit times become faster, and charges were lower. ED reported significant benefits with sharing clinical information. NHIN implementation throughout the ED has increased the quality of healthcare; duplicated tests and drug usage were determined, and a reduction of the ED length of stay was also achieved.